Human Endogenous Metabolite Compound Library


The human body produces a variety of metabolites – small molecules that play essential roles in maintaining physiological processes. These metabolites have tremendous potential as therapeutic targets, but research on their medicinal properties has been limited due to the lack of available compounds. The Human Endogenous Metabolite Compound Library (HEMCL) addresses this gap by offering a collection of diverse metabolites that can be screened for potential therapeutic applications. In this blog post, we will explore the significance of the HEMCL and highlight the key role it plays in drug discovery.

Key Points

  1. A Unique Library of Endogenous Metabolites: The HEMCL is a collection of small molecules that naturally occurs in the human body. These metabolites are produced as part of normal physiological processes, including energy metabolism, biosynthesis of macromolecules, and signal transduction. As natural products, endogenous metabolites have undergone extensive biological evolution and have been optimized for their specific biochemical functions. Thus, they exhibit excellent drug-like properties, such as high activity and selectivity, and have minimal toxicity issues.
  2. Highly Relevant for Disease Research and Therapeutic Targets: Many diseases, such as cancer, diabetes, and neurological disorders, are associated with metabolic dysregulation. By screening the HEMCL against specific disease models, researchers can identify metabolites that are involved in these physiological pathways and explore potential therapeutic targets. Researchers can also investigate metabolites that are relevant to specific biological processes, such as inflammation or cell signaling, and determine their potential therapeutic applications.
  3. Targeting Undiscovered Areas of Medicinal Chemistry: The HEMCL offers an opportunity to explore new areas of medicinal chemistry. Despite being produced naturally in the body, HEMs have remained relatively unexplored for therapeutic applications. Research on these metabolites can uncover new mechanisms of action and novel approaches to treating diseases, which differ from conventional drug discovery methods. HEMs possess a unique set of properties that make them promising candidates for drug development, such as biological stability, specificity, and accessibility.
  4. Expanding Drug Discovery and Development: The HEMCL broadens the scope of drug discovery by providing new leads and insights that are not achievable by traditional compound libraries. By utilizing the HEMCL, researchers can accelerate target identification, lead optimization, and drug development stages. The library presents a cost-effective and resourceful approach to drug discovery, as many metabolites are readily available and can be synthesized relatively easily.
  5. Collaborative Opportunities: The HEMCL provides ample opportunities for collaboration within the research community. Many institutions and organizations are working on compiling and screening metabolites within this library, creating an ecosystem of shared knowledge and resources. Collaborative efforts provide access to new data and methodologies that can enhance future drug discovery and development.
  6. Potential for Personalized Medicine: The HEMCL has the potential to revolutionize the field of personalized medicine. Metabolomics, the study of small molecules, has the potential to provide personalized diagnoses and treatments tailored to an individual’s unique biochemistry. By further analyzing the metabolites in the HEMCL, researchers can gain insights into metabolic variations between individuals and develop targeted therapies that consider individual patient responses.


The HEMCL offers a unique approach to drug discovery, tapping into the body’s own chemistry to identify potential therapeutic targets. The library provides a cost-effective and resource-efficient approach to drug development, enabling researchers to explore new areas of medicinal chemistry and accelerate drug discovery and development stages. By promoting collaborative efforts, the HEMCL fosters a shared knowledge environment that benefits the entire research community. With the potential for personalized medicine, the HEMCL holds promise in providing innovative treatments for a variety of diseases and improving patient outcomes.